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Pathogen Testing

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What is the difference between infection and disease?

Disease-causing microbes are often found in the human microbiome. So, when does the presence of pathogenic microbes indicate an infection? And when does the presence of infection explain disease?   What is an infection? What is a disease? A disease associated with microbes is the outcome of interaction(s) between a microbe(s) and its host in [...]

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Latent Infections: Pitfalls and Promises

Photo by Павел Сорокин via Pexels Recently a US man became the first to receive a pig heart transplant. While this new technology opens many possibilities, it is important to address the pitfalls. Despite numerous safeguards including extensive pathogen screening and protection, the man seems to have acquired a virus from a latent infection in [...]

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Endothelial Cells: Playing Telephone on a Football Field

Source: Photo by Robert Hernandez Villalta from Pexels The endothelium is a membrane made of cells that primarily lines the inside of the heart and blood vessels. Not only does the membrane fill space, it also participates in a complex bio-signaling that scientists are only beginning to understand. Infections that disrupt the endothelium can cause [...]

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Revisiting Bartonella Digital ePCR and the Triple Draw Approach

This year Galaxy Diagnostics released Bartonella Digital ePCR™, which combines ddPCR technology with BAPGM™ enrichment to enhance direct detection of infection. Although replacing qPCR with ddPCR has increased the sensitivity of our ePCR™ platform, collecting samples on three different days (known as Triple Draw) is still the recommended approach for confirming a bartonellosis diagnosis.   [...]

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